Purpose:To investigate the difference in sparing normal liver tissue between 4D-CT and active breathing coordinator (ABC) in the radiotherapy of Hepatocellular carcinoma(HCC) applying RapidArc. Methods:Ten patients with HCC underwent 3D-CT at end inspiration hold(EIH) associated with active breathing coordinator(ABC)
ثبت نشده
چکیده
ID: 18059 Title: 4D-CT and Active Breathing Coordinator Play Similar Role in Sparing Normal Liver Tissue in the Radiotherapy of Hepatocellular Carcinoma Purpose:To investigate the difference in sparing normal liver tissue between 4D-CT and active breathing coordinator (ABC) in the radiotherapy of Hepatocellular carcinoma(HCC) applying RapidArc. Methods:Ten patients with HCC underwent 3D-CT at end inspiration hold(EIH) associated with active breathing coordinator(ABC) ,and 4D-CT scan. The 4D-CT images were sorted in to 10 serious CT images according respiratory phase. Gross tumor volumes(GTVs) were manually contoured on different CT images. The individual internal gross target volume(IGTV) was obtained from 10 GTVs of 4D-CT images. Plan target volumes (PTVs) were obtained based on IGTV and GTVEIH. PTV1 was obtained from IGTV plus 5 mm margins isotropically, and PTV2 was obtained from GTVEIH using 8 mm margins isotropically. RapidArc plans were designed on PTV1 and PTV2, for PTV1 RapidArc plans with one single whole arc were applied and for PTV2 three 135°arcs, and name RapidArc1 and RapidArc2. Dosimetric differences were compared. Results:There were no significant difference in conformity index (0.93±0.05 Vs 0.93±0.03), homogeneity index(1.08±0.01 Vs 1.08±0.01) , the D1%(54.44±0.36 Gy Vs54.68±0.47 Gy) and D99%(49.18±0.48Gy Vs 49.00±0.34 Gy) between RapidArc1 and RapidArc2(P>0.05). There were no significant differences in the mean dose(8.23±1.5Gy Vs 7.63±3.00Gy),V5(46.64±19.31Vs43.29±19.94), V10(28.73±11.54 Vs 28.23±12.37), V15(17.87±6.61 Vs 18.20±7.55), V20(11.62±4.39 Vs 11.83±4.58), V25(7.71±2.91Vs7.58±2.79),V30(5.14±2.01Vs5.05±1.79), V35(3.41±1.35Vs 3.35±1.21) and V40(2.12±0.86Vs2.06±0.75) between RapidArc1 andRapidArc2 (P>0.05). Conclusions:The RapidArc plans with three 135°arcs associated could achieve similar dose delivery as the plans with single whole arc, and 4D-CT and ABC could play similar role in sparing normal liver tissue assuring the accuracy of target volume in radiotherapy of HCC.
منابع مشابه
Dosimetric differences among volumetric modulated arc radiotherapy (RapidArc) plans based on different target volumes in radiotherapy of hepatocellular carcinoma
We investigated the dosimetric differences among volumetric-modulated arc radiotherapy (RapidArc, RA) plans designed for various target volumes in hepatocellular carcinoma (HCC). Ten HCC patients underwent 3D-CT scanning at free breathing (FB), 3D-CT at end inspiration hold (EIH) assisted by an Active Breathing Coordinator (ABC), and 4D-CT scanning. Gross tumor volumes (GTVs) were manually cont...
متن کاملFirst MRI application of an active breathing coordinator
A commercial active breathing coordinator (ABC) device, employed to hold respiration at a specific level for a predefined duration, was successfully adapted for magnetic resonance imaging (MRI) use for the first time. Potential effects of the necessary modifications were assessed and taken into account. Automatic MR acquisition during ABC breath holding was achieved. The feasibility of MR-ABC t...
متن کاملFDG-avid portal vein tumor thrombosis from hepatocellular carcinoma in contrast-enhanced FDG PET/CT
Objective(s): In this study, we aimed to describe the characteristics of portal vein tumor thrombosis (PVTT), complicating hepatocellular carcinoma (HCC) in contrast-enhanced FDG PET/CT scan. Methods: In this retrospective study, 9 HCC patients with FDG-avid PVTT were diagnosed by contrast-enhanced fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT), which is a comb...
متن کاملThe use of the Active Breathing Coordinator throughout radical non-small-cell lung cancer (NSCLC) radiotherapy.
PURPOSE To assess feasibility and reproducibility of an Active Breathing Coordinator (ABC) used throughout radical radiotherapy for non-small-cell lung cancer, and compare lung dosimetric parameters between free-breathing and ABC plans. METHODS AND MATERIALS A total of 18 patients, recruited into an approved study, had free-breathing and ABC breath-hold treatment plans generated. Lung volume,...
متن کاملThe Role of Active Breathing Control-Moderate Deep Inspiration Breath-Hold (ABC-mDIBH) Usage in non-Mastectomized Left-sided Breast Cancer Radiotherapy: A Dosimetric Evaluation
The aim of this study is to evaluate the dosimetric impact of utilizing Active Breathing Control-moderate deep inspiration breath-hold (ABC-mDIBH) technique in early-stage left-sided breast cancer radiotherapy (RT). Twenty-five patients with left-sided early-stage breast cancer undergoing breast-conserving surgery referred to our department for adjuvant radiotherapy between October 2010 and Oct...
متن کامل